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PYRAZOLE DERIVATIVES, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF
专利权人:
发明人:
申请号:
EP03792760.5
公开号:
EP1548024B1
申请日:
2003.08.21
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc. one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc. R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc. X represents a single bond, O or S Y represents an optionally substituted C1-6 alkylene group etc. Z represents -RB, -CORC etc. in which RB represents an optionally substituted C1-6 alkyl group etc. and RC represents --> an optionally substituted C1-6 alkyl group etc., R4 represents H, an optionally substituted C1-6 alkyl group etc. and R3, R5 and R6 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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