LE-DIGARE Terri (FR),ЛЕ-ДИГАРЕ Тьерри (FR),KASARA Patrik (FR),КАСАРА Патрик (FR),STARK Zherom-Benua (FR),СТАРК Жером-Бенуа (FR),ANLEN Zhan-Mishel (FR),АНЛЕН Жан-Мишель (FR),DEJVIDSON Dzhejms Eduard Po,LE-DIGARE Terri,ЛЕ-ДИГАРЕ Тьерри,KASARA Patrik,КАСАРА Патрик,STARK Zherom-Benua,СТАРК Жером-Бенуа,ANLEN Zhan-Mishel,АНЛЕН Жан-Мишель,DEJVIDSON Dzhejms Eduard Pol,ДЕЙВИДСОН Джеймс Эдуард Пол,MARRI Dzhe
申请号：
RU2014134388
公开号：
RU0002646223C2
申请日:
2013.01.23
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: pharmaceutics.SUBSTANCE: invention relates to novel heterocyclic compound of formula (I), or to its enantiomer and diastereoisomer, and to its additive salt with pharmaceutically acceptable acid or base, where X and Y are a carbon atom or a nitrogen atom, and they can not simultaneously represent two carbon atoms or two nitrogen atoms； Het fragment of the group an optionally substituted, aromatic or nonaromatic 5-7-membered ring containing, in addition to nitrogen, 1 to 3 hetero atoms selected from O, S and N, wherein the nitrogen may be substituted with a group representing a hydrogen atom, (C1-C6)alkyl group or a group -C(O)-O-Alk； R1 and R2 – (C1-C6)alkyl group, or R1 and R2 with the nitrogen atom carrying them, form a 4- to 7-membered heterocycloalkyl which may contain, in addition to the nitrogen atom, another heteroatom selected from oxygen, SO2 and NR, where R is (C1-C6)alkyl group, (C1-C6)alkylsulfonyl group, (C1-C6)polyhaloalkyl group or a group -C(O)-O-Alk； R3 represents (C1-C6)alkyl group, (C2-C6)alkenyl group, (C2-C6)alkynyl group, a cycloalkyl group, (C3-C4)cycloalkyl-(C1-C6)an alkyl group or a heteroaryl group； R4 is an aryl, heteroaryl, cycloalkyl or (C1-C6)alkyl group； R5 represents a hydrogen atom； Ra, Rb, Rc and Rd independently of each other, are a hydrogen atom, a halogen atom, (C1-C6)alkyl group, (C1-C6)alkoxy group, a hydroxy group, (C1-C6)polyhaloalkyl group, or a trifluoromethoxy group, or substituents of one of the pairs (Ra,Rb), (Rb,Rc) or (Rc,Rd) together with the carbon atoms carrying them form a 5-7-membered ring which may contain 1 to 2 heteroatoms selected from oxygen, wherein one or more of the ring carbon atoms defined above can be deuterated； “aryl” means a phenyl, naphthyl, biphenyl or indenyl group； “heteroaryl” means any mono- or bicyclic 5-10-membered group having at least one aromatic moiety and containing from 1 to 2 heteroatoms, selected from O, S and N； “cycloalkyl” means any mono- or bicyclic, non-aromatic, carbocyc
