Novel 2,3-Dihydro-1H-imidazopyrimidin-5-one and this 1,2,3,4-tetrahydropyrimidopyrimidin-6-one Derivatives Comprising a Substituted Morpholine, Preparation Thereof and Pharmaceutical Use Thereof
The invention relates to the novel products of formula (I) with p, q=0, 1 or 2； R1=phenyl, pyridyl； —(CH2)m—Ra； alkylene； cycloalkyl； heterocycloalkyl； alkyl； —SO2 —Rb； —CO—Re； m=1 or 2； Ra=aryl, heteroaryl, —CO-cycloalkyl, —CO-heterocycloalkyl, —CO—Rb, —C(Rb)═N—ORc, —CO 2 Rd, —CONRxRy； Rb=alkyl, aryl, heteroaryl； Rc=H, alkyl； Rd=alkyl, cycloalkyl； Re=alkyl, cycloalkyl, aryl, heteroaryl； NRxRy with Rx,Ry=H, alkyl, cycloalkyl, alkoxy, phenyl, or form with N a ring with optionally O, N； R2, R3=H, alkyl, CF 3, or form with C a ring with optionally O, S and N； R4=H, F, Cl, CH3 or CN； the morpholine is substituted with Me, and optionally substituted with F, OH； or is (Formula 1a) and the isomer of configuration R,R (Formula 1b) these products being in all the isomer forms and the salts, as medicaments, in particular as anticancer medicaments.
