Calitor Sciences, LLC;Sunshine Lake Pharma Co., Ltd.
发明人:
XI, Ning
申请号：
ES14754663
公开号：
ES2674705T3
申请日:
2014.02.15
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound having Formula (I): ** Formula ** or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate or a pharmaceutical salt thereof, in which: W1 is N or CRc ； each of W2 and W3 is independently CRc； Z is CN, N3, or X is H, D, (C1-C6) alkyl, cycloalkyl (C3-C6), heterocyclyl (C3-C6), alkylene- (C1-C4) -cycloalkyl (C3-C6) or - alkylene (C1-C4) -heterocyclyl (C3-C6), wherein each of alkyl (C1-C6), cycloalkyl (C3-C6), heterocyclyl (C3-C6), alkylene- (C1-C4) -cycloalkyl ( C3-C6) and -alkylene (C1-C4) -heterocyclyl (C3-C6) is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, Br, CN, N3, ORa, SRa, NRaRb, - C (>； = O) NRaRb, (C1-C3) alkyl, halo (C1-C3) alkyl, (C2-C4) alkenyl and (C2-C4) alkynyl； Y is (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) heterocyclyl, (C1-C4) alkylene- (C3-C6) alkylene- (C1- C4) -heterocyclyl (C3-) C6), (C2-C6) alkenyl, (C2-C6) alkynyl, 5-10 membered aryl (C6-C10) or heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, in where each of (C1-C6) alkyl, cycloalkyl (C3-C6), heterocyclyl (C3-C6), alkylene- (C1-C4) -cycloalkyl (C3-C6), alkylene- (C1-C4) - heterocyclyl ( C3-C6), alkenyl (C2-C6), alkynyl (C2-C6), aryl (C6-C10) and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F , Cl, Br, CN, N3, ORa, SRa, NRaRb, -C (>； = O) NRaRb, (C1-C6) alkyl, halo (C1-C6) alkyl, alkenyl (C2-C6), alkynyl (C2-C6) ), alkylene- (C1-C4) -CN, alkylene- (C1-C4) -ORa, alkylene- (C1-C4) -NRaRb, aryl (C6-C10) and 5-10 membered heteroaryl； R1 is H, D, Cl, ORa, NRaRb, (C1-C6) aliphatic or cycloalkyl (C3-C6), wherein each of the aliphatic (C1-C6) and cycloalkyl (C3-C6) is optionally substituted with 1 , 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N3, ORa, SRa and NRaRb； each Ra and Rb is independently H, (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) heterocyclyl, (C6-C10) aryl, 5-10 membered heteroaryl com
