Calitor Sciences, LLC;Sunshine Lake Pharma Co., Ltd.
发明人:
XI, Ning
申请号：
ES13855522
公开号：
ES2661380T3
申请日:
2013.11.10
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula (I): ** (See formula) ** or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate or a pharmaceutically acceptable salt thereof, where: each of W1, W2 and W3 is independently N or CRc； Z is CN； Y is (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) heterocyclyl, (C1-C4) -alkyl (C3-C6) -alkyl (-C1-C4) -heterocyclyl (C3-) C6), (C2-C6) alkenyl, (C2-C6) alkynyl, 5-10 membered aryl (C6-C10) or heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, where each of the (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) heterocyclyl, (C1-C4) alkylene (C3-C6) alkyl, (C1-C4) alkylene-heterocyclyl ( C3-C6), alkenyl (C2-C6), alkynyl (C2-C6), aryl (C6-C10) and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F , Cl, Br, CN, N3, ORa, SRa, NRaRb, -C (>； = O) NRaRb, (C1-C6) alkyl, halo (C1-C6) alkyl, alkenyl (C2-C6), alkynyl (C2-C6) ), - (C1-C4) alkylene -CN, -C1-C4 alkylene -ORa, (C1-C4) -NRaRb, aryl (C6-C10) and 5-10 membered heteroaryl； R1 is ORa； each Ra and Rb is independently H or (C1-C6) alkyl, wherein (C1-C6) alkyl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N3, OH , NH2, (C1-C6) alkoxy and (C1-C6) alkylamino； and each Rc is independently H, D, F, Cl, Br, I, N3, CN, OH, NH2, (C1-C6) alkyl, (C1-C6) alkoxy, (C1-C6) alkylamino, (C3-) cycloalkyl C6), heterocyclyl (C3-C6), aryl (C6-C10) or 5-10 membered heteroaryl comprising 1, 2, 3 or 4 heteroatoms independently selected from O, S and N, wherein each of the alkyl ( C1-6), alkoxy (C1-C6), alkylamino (C1-C6), cycloalkyl (C3-C6), heterocyclyl (C3-C6), aryl (C6-C10) and 5-10 membered heteroaryl is optionally substituted with 1, 2, 3 or 4 substituents independently selected from D, F, Cl, CN, N3, OH, NH2, (C1-C6) alkyl, cycloalkyl (C3-C6), haloalkyl (C1-C6), alkoxy (C1- C6) and alkylamino (C1-C6).Un compuesto de Fórmula (I): **(Ver fórmula)** o un estereoisómero
