Bi-aryl derivatives of formula (I), their preparation and their therapeutic application as EP2 agonists in, for example, glaucoma.or one of its prodrugs, in which:R1 represents, independently from each other, H or an halogen,R2 represents H, an halogen, or a (C1-C6)alkyl,R3 represents, independently from each other, H, an halogen, -OH, or a (C1-C6)alkyl.