John Emmerson Campbell;Philip Jones;Michael Charles Hewitt
发明人:
John Emmerson Campbell,Philip Jones,Michael Charles Hewitt
申请号：
US13347541
公开号：
US08765760B2
申请日:
2012.01.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided herein are compounds of formula (I):A-L-B (I)and pharmaceutically acceptable salts and stereoisomers thereof, wherein A iswherein X is (i) CR1 or N, or (ii) O or NR2, each Y is independently N or CR3, and each Z is independently N or C, wherein R1, R2 and R3 are defined in the specification； L is a linker, and B is a multicyclic ring； methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are inhibitors of phosphodiesterases and useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, e.g., neurological disorders, psychosis, schizophrenia, obesity and diabetes.
