James R. Falsey;Andreas Reichelt;Jennifer R. Allen;Michael J. Frohn;Paul E. Harrington;Alexander J. Pickrell;Thomas T. Nguyen;Essa Hu Harrington;Matthew R. Kaller;Ning Chen;Shannon Rum;Roxanne K. Kunz
发明人:
Jennifer R. Allen,Ning Chen,James R. Falsey,Michael J. Frohn,Paul E. Harrington,Essa Hu Harrington,Matthew R. Kaller,Roxanne K. Kunz,Thomas T. Nguyen,Alexander J. Pickrell,Andreas Reichelt,Shannon Rum
申请号：
US12639931
公开号：
US08637500B2
申请日:
2009.12.16
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Pyridine and pyrimidine compounds:or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined in the specification；or a pharmaceutically acceptable salt thereof, wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, and ring A are as defined in the specification； andor a pharmaceutically acceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6, R7, R9, X1, X2, and ring A are as defined in the specification； compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.
