ALLEN, JENNIFER R.,CHEN, NING,FALSEY, JAMES R.,FROHN, MICHAEL,HARRINGTON, PAUL,HU, ESSA,KALLER, MATTHEW R.,KUNZ, ROXANNE,MERCEDE, STEPHANIE J.,NGUYEN, THOMAS T.,PICKRELL, ALEXANDER J.,REICHELT, ANDREA
申请号：
CA2746307
公开号：
CA2746307C
申请日:
2009.12.16
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
Pyridine and pyrimidine compounds: (I)； or a pharmaceuticallyacceptable salt thereof, wherein m, n, R1, R2, R3, R4,R5, R6, R7, X1, X2, X3, X4, X5, X6, X7, X8, and Y are as defined inthe specification； (II)； or a pharmaceutically acceptable salt thereof,wherein ring A, m, n, y, R2, R3, R4, R5, R6, R7, R8, R9, X1, X2, andring A are as defined in the specification； and (III)； or a pharmaceuticallyacceptable salt thereof, wherein m, n, y, R2, R3, R4, R5, R6,R7, R9, X1, X2, and ring A are as defined in the specification； compositionscontaining them, and processes for preparing such compounds.Provided herein also are methods of treating disorders ordiseases treatable by inhibition of PDE10, such as obesity, non-insulindependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsivedisorder, and the like.
