The present invention relates to a pharmaceutical composition comprising an aqueous suspension of: (i) crystalline N-(3,4-dichlorophenyl)-3-(pyridin-4-yl)-7-oxabicyclo[2.2.1]heptane-2-carboxamide or a pharmaceutically acceptable salt thereof； and (ii) a surfactant comprising a water-soluble co-polymer characterized by ＞ 5% solubility in water at 25oC. The compositions provide extended release of N-(3,4-dichlorophenyl)-3-(pyridin-4-yl)-7-oxabicyclo[2.2.1] heptane-2-carboxamide, and are suitable for intra-articular injection to a joint of a patient suffering from arthritis, joint injury or cartilage injury.本發明係關於一種包含以下之水性懸浮液之醫藥組合物：(i)結晶N-(3,4-二氯苯基)-3-(吡啶-4-基)-7-氧雜雙環[2.2.1]庚烷-2-甲醯胺或其醫藥學上可接受之鹽；及(ii)界面活性劑，其包含特徵在25℃下＞ 5%水溶性之水溶性共聚物。該等組合物提供N-(3,4-二氯苯基)-3-(吡啶-4-基)-7-氧雜雙環[2.2.1]庚烷-2-甲醯胺之延長釋放，且適用於關節內注射至罹患關節炎、關節損傷或軟骨損傷之患者之關節。
