LEE, FRANK WEN-CHI,李 文机,李 文機,LEE, YUAN-MING,李元铭,李元銘,TSAO, YEOU-PING,曹友平,HO, TSUNG-CHUAN,何宗权,何宗權
申请号：
TW108112196
公开号：
TW202010514A
申请日:
2019.04.08
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
A method for treating and/or preventing osteoarthritis includes administering to a subject in need thereof a pharmaceutical composition comprising a PEDF-derived short peptide (PDSP) or a variant of the PDSP, wherein the PDSP comprises residues 93-106 of human pigmented epithelium-derived factor (PEDF), and wherein the variant of the PDSP contains serine-93, alanine-96, glutamine-98, isoleucine-103, isoleucine-104, and arginine 106 of the PDSP and contains one or more amino acid substitutions at other positions, wherein residue location numbers are based on those in the human PEDF.本發明係關於一種治療及/或預防骨關節炎之方法，其包括向有需要之個體投與包含PEDF衍生之短肽(PDSP)或該PDSP之變體的醫藥組合物，其中該PDSP包含人類色素上皮衍生因子(PEDF)之殘基93至106，且其中該PDSP之變體含有該PDSP之絲胺酸-93、丙胺酸-96、麩醯胺酸-98、異白胺酸-103、異白胺酸-104及精胺酸106且在其他位置處含有一或多個胺基酸取代，其中殘基位置編號係基於人類PEDF中之彼等。
