經取代之吡啶並[3,4-B]吲哚及其作為藥物之用途农业专利-农业专业知识服务系统

发明人:: GRETZKE, DIRK,格雷茨基　德克,RITZELER, OLAF,瑞兹勒　欧若夫,瑞茲勒　歐若夫,HEINELT, UWE,海内特　乌韦,海內特　烏韋,WEHNER, VOLKMAR,魏纳　福尔克马尔,魏納　福爾克馬爾,SCHMIDT, FRIEDEMANN,施密特　弗来德曼,施密特　弗來德曼,格雷茨基德克,瑞兹勒欧若夫,瑞茲勒歐若夫,海内特乌韦,海內特烏韋,魏纳福尔克马尔,魏納福爾克馬爾,施密特弗来德曼,施密特弗來德曼

摘要：: The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula I, in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.本申請涉及式I的8-芳基-取代的和8-雜芳基-取代的9H-吡啶並[3,4-b]吲哚，其中A、E、G、R1至R6和R10如在請求項中定義，其刺激軟骨生成和軟骨基質合成且可用於治療其中期望受損軟骨的再生的軟骨障礙和病症，例如關節疾病諸如骨關節炎。本申請還涉及用於合成式I化合物的方法、它們作為藥物的用途以及包含它們的醫藥組合物。