A joint injection as a restoring agent for damaged cartilage matrix is disclosed. The joint injection comprises 0.02-0.3 ppm of β-estradiol, 1% (w/v) of hyaluronic acid and a pharmaceutical acceptable adjuvant.一種關節注射劑,係包含:0.02~0.3ppm之雌二醇及以重量體積百分比計為1%之透明質酸,其餘成分為一醫藥學上可接受之載劑,該關節注射劑係作為受損軟骨基質之修復製劑。