DAVID URECH,ADRIAN AUF DER MAUR,ALCIDE BARBERIS,PETER LICHTLEN
申请号：
NZ60959707
公开号：
NZ609597A
申请日:
2007.07.10
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
A pharmaceutical composition formulated for oral application to the intestine comprising a soluble short chain variable fragment (scFv) antibody or a functional antibody fragment capable of crossing an epithelial layer in less than 4 hours wherein said scFv antibody or functional antibody fragment reveals a midpoint of transition in guanidinium hydrochloride titration of at least 1.5M and wherein said scFv antibody or functional antibody fragment is capable of crossing said epithelial layer in the absence of a penetration enhancer.
