РИИС Бенте (CH),ХЕНРИКСЕН Ким (DK),КУМАР Раджиндер (GB)
申请号：
RU2012130439/15
公开号：
RU2012130439A
申请日:
2010.12.17
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of reducing insulin resistance in a subject comprising administering balaglitazona, with this method at the same time 1) enhances or retains bone density or bone mineral content, or both, and / or 2) reduces the risk or incidence of bone fractures and / or 3) reduce the rate of bone degradation and / or 4) decreases the bone loss.2. The method of claim 1, wherein the subject is a human.3. The method of claim 1, wherein the rate of bone formation by osteoblasts is maintained during insertion.4. The method of claim 1, wherein the improved control of blood glucose levels in a subject.5. The method of claim 1, wherein the subject has an increased risk of bone fracture because the subject demographic data relating to age, sex and weight.6. The method of claim 1, wherein the subject is an adult, and balaglitazon administered to a subject in a dose of from about 5 to 15 mg per day.7. The method of claim 6, wherein the dose is from about 9 to 12 mg per day.8. The method of claim 6, wherein the dose is from about 9.5 to 10.5 mg per day.9. The method of claim 6, wherein the dose is about 5 mg per day.10. The method of claim 1, wherein the subject receives an additional insulin therapy.11. The method of claim 11, wherein the subject receives a constant insulin.12. The method of claim 1, wherein the subject has a condition comprising one or more of type 2 diabetes, dislipidimii, hyperglycemia, hyperinsulinemia, insulin resistance, obesity, cardiovascular complications, atherosclerosis, hypertension, impaired tolerance glucose, impaired fasting glucose, increased levels of fatty acids in the plasma, elevated levels of triglycerides in plasma and increased levels of VLDL in plasma.13. The method of claim 1, wherein the subject has a condition comprising one or more of osteoporosis, achondroplasia (Chondrodystrophy), bone and joint infections, bone cancer, bone fractures, craniosynostosis, curvature of the spine, chondroma, fibrodisplations ossificans progressiva, fibr
