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AXON DEGENERATION MODULATION
专利权人:
ЖЕНЕНТЕК; ИНК. (US)
发明人:
ЛЬЮКОК Джозеф Вэсли (US),ПОЗНЯК Кристин (US),СЕНГУПТА-ГОШ Арундати (US)
申请号:
RU2012120783/15
公开号:
RU2012120783A
申请日:
2010.10.21
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A method of inhibiting or preventing degeneration of a central nervous system (CNS) neuron or part thereof, comprising administering to the CNS neuron an agent that inhibits the activity or expression of a double specificity leukin fastener kinase (DLK) .2. The method according to claim 1, wherein degeneration is inhibited or prevented in the axon or body part of the CNS neuron cell. The method according to claim 1, wherein the central nervous system neuron is selected from the group consisting of a cerebral granular neuron, cortical neuron, and hippocampal neuron. The method of claim 1, wherein the CNS neuron is not a dopaminergic neuron. The method according to claim 1, wherein said administration results in at least a 10% reduction in degeneration of a population of neurons compared to a population of neurons not treated with the agent. The method according to any one of claims 1 to 5, wherein the agent is a DLK signal transmission inhibitor. The method according to any one of claims 1 to 5, wherein the agent is a DLK expression inhibitor. The method according to any one of claims 1 to 5, wherein the agent is selected from the group consisting of an antibody, short interfering RNA (siRNA), a polypeptide, a peptide antibody, an antisense polynucleotide, an aptamer, a small molecule, and a polysaccharide. The method of claim 8, wherein the antibody is selected from the group consisting of a polyclonal antibody, a monoclonal antibody, a chimeric antibody, a humanized antibody, an Fv fragment, a Fab fragment, a Fab'fragment, and an F (ab ') fragment. The method of claim 8, wherein the agent is selected from the group consisting of a siRNA molecule targeted at DLK, a siRNA molecule targeted at JNK1, a siRNA molecule targeted at JNK2, a small molecule, dominantly negative, JNK3 siRNA molecule1. Способ ингибирования или профилактики дегенерации нейрона центральной нервной системы (ЦНС) или его части, предусматривающий введение в нейрон ЦНС средства, которое ингибируе
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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