A fatigue detection and refreshing device for vehicle comprises at least one physiological signal sensing device, at least one environmental signal sensing device, a physiological signal and environmental signal processor, a fatigue evaluating system and a stimulation device. The physiological signal and environmental signal processor gets drivers physiological signal and the environmental signal in the vehicle timely via the physiological signal sensing device and the environmental signal sensing device, and sends the signals to the fatigue evaluating system after the signals are analyzed and treated, so as to affirm the fatigue degree of the driver. Moreover, the fatigue evaluating system also sends control signals to the stimulation device, thus producing stimulation signals to make the driver refresh.本發明係一種車用疲勞偵測暨提神裝置,包含至少一生理訊號感測裝置、至少一環境訊號感測裝置、一生理訊號暨環境訊號處理器、一疲勞判斷系統及一提神刺激裝置,其中,生理訊號暨環境訊號處理器定時透過生理訊號感測裝置及環境訊號感測裝置分別擷取駕駛人生理訊號及車內環境訊號,經分析處理後傳送給疲勞判斷系統,使該疲勞判斷系統確認駕駛人疲勞程度,且透過該疲勞判斷系統送出控制訊號至該提神刺激裝置,藉由該提神刺激裝置產生刺激訊號讓駕駛人維持清醒。生理訊號感測裝置‧‧‧10心跳感測器‧‧‧11電接觸片‧‧‧111訊號處理單元‧‧‧112血氧偵測器‧‧‧12光接觸套‧‧‧121訊號處理單元‧‧‧122環境訊號感測裝置‧‧‧20二氧化碳感測器‧‧‧21生理訊號暨環境訊號處理器‧‧‧30疲勞判斷系統‧‧‧40微電腦控制器‧‧‧41提神刺激裝置‧‧‧50