A physiology signal sensing device includes an elastic pad and a deformation sensing unit. The elastic pad is for contacting with a human body and corresponding a blood vessel of the human body. The deformation sensing unit is disposed in the elastic pad and includes a conductive element. The conductive element is deformed according to the vibration of the blood vessel, and the resistor value of the conductive element is varied according to the deformation of the conductive element.一種生理訊號感測裝置,包括一彈性墊以及一形變感測單元。彈性墊用以接觸於一人體,並對應於上述人體之一血管。形變感測單元設置於上述彈性墊內,並包括一導電元件。上述導電元件對應於上述血管之振動產生形變,且上述導電元件之電阻值對應於上述導電元件之形變產生變動。1‧‧‧生理訊號感測裝置10‧‧‧感測器11‧‧‧彈性墊111‧‧‧接觸面112‧‧‧壓力面12‧‧‧形變感測單元121‧‧‧感測本體122‧‧‧導電元件13‧‧‧彈性片20‧‧‧壓力元件21‧‧‧固定帶22‧‧‧殼體221‧‧‧扣合孔222‧‧‧容置槽23‧‧‧彈性元件24‧‧‧蓋體242‧‧‧扣合塊
