HUMAN IGG1 FC REGION VARIANTS AND USES THEREOF

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专利权人:

GENMAB B.V.

发明人:

PARREN, PAUL,BEURSKENS, FRANK,DE JONG, ROB, N.,VERPLOEGEN, SANDRA,LABRIJN, ARAN, FRANK,SCHUURMAN, JANINE

申请号：

SG11201505286T

公开号：

SG11201505286TA

申请日:

2013.01.10

申请国别(地区):

SG

年份:

2015

代理人:

摘要：

Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved complement-dependent cytotoxicity (CDC).

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