Paul PARREN,Frank BEURSKENS,Rob N. DE JONG,Sandra VERPLOEGEN,Aran Frank LABRIJN,Janine SCHUURMAN
申请号：
US14760135
公开号：
US20150353636A1
申请日:
2013.01.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved complement-dependent cytotoxicity (CDC).
