Human IgG1 Fc region variants and uses thereof

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专利权人:

Genmab B.V.

发明人:

Parren, Paul,Beurskens, Frank,De Jong, Rob N.,Verploegen, Sandra,Labrijn, Aran Frank,Schuurman, Janine

申请号：

AU2013372331

公开号：

AU2013372331A1

申请日:

2013.01.10

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc: Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved complement-dependent cytotoxicity (CDC).

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