Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses

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专利权人:

Merck Patent GmbH

发明人:

Gillies, Stephen D.

申请号：

AU2007271398

公开号：

AU2007271398B2

申请日:

2007.07.04

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

Compositions and methods directed to enhancing the effectiveness of IL-2 in stimulating the immune system is disclosed. According to one method, an antagonist directed against the CD25 subunit of the high-affinity IL-2 receptor complex is administered in conjunction with IL-2. The CD25 antagonist may be an anti-CD25 antibody. According to another method, an anti-IL-2 antibody is administered in conjunction with IL-2. In another method, a mutant IL-2 with diminished ability to bind the CD25 subunit of the high-affinity IL-2 receptor complex is administered. In another method, an CD4 antagonist is administered in conjunction with IL-2 in order to stimulate the immune system.

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