CZECHTIZKY, Werngard,WESTON, John,RACKELMANN, Nils,KRAFT, Volker,ARNDT, Petra,WIRTH, Klaus,GOEGELEIN, Heinz,RITZELER, Olaf
申请号：
ES14710222
公开号：
ES2614050T3
申请日:
2014.03.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of the formula I, in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any proportion, or a pharmaceutically acceptable salt thereof, ** Formula ** wherein Ar is phenyl which is unsubstituted or substituted with one or more R0 substituents the same or different； R0 is selected from the series consisting of halogen, alkyl- (C1-C6), cycloalkyl- (C3-C7), cycloalkyl- (C3-C7) -alkyl- (C1-C4), HO-, -alkyl- ( C1-C6) -O-, cycloalkyl- (C3-C7) -O- and cycloalkyl- (C3-C7) -alkyl- (C1-C4) -O-, and two R0 groups attached to adjacent ring carbon atoms in Ar, together with the carbon atoms that carry them, they can form a monounsaturated ring of 5 members to 7 members comprising 0, 1 or 2 same or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, and which is unsubstituted or substituted with one or more same or different substituents selected from the series consisting of fluorine and alkyl- (C1-C4)； R1 is hydrogen or one or more same or different substituents selected from the series consisting of fluorine and alkyl- (C1-C4)； R2 is selected from the series consisting of hydrogen, alkyl- (C1-C6), HO-, -alkyl- (C1-C6) -O-, -alkyl- (C1-C6) -C (O) - O- , phenyl-C (O) -O-, Het1-C (O) -O-, R5-N (R6) -, R7-C (O) -N (R8) -, R7-S (O) 2- N (R8) -, R9-N (R10) -C (O) -N (R8) - and R5-N (R6) -C (O) -, where alkyl- (C1-C6) is unsubstituted or substituted with one or more same or different R20 substituents； R3 is selected from the series consisting of hydrogen and alkyl- (C1-C6), wherein alkyl- (C1-C6) is unsubstituted or substituted with one or two identical or different substituents selected from the series consisting of cycloalkyl - (C3-C7), phenyl, HO- and alkyl- (C1-C4) -O-； or the groups R2 and R3 together are oxo: R4 is hydrogen or one or more same or different substituents selected from the series consisting of halogen, alkyl- (C1-C4) and alkyl- (C1-C4) -O-； R5 and R6 are independently selected from each other
