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ACYLAMINO-SUBSTITUTED DERIVATIVES OF CONDENSED CYCLOPENTACARBOXYLIC ACIDS AND THEIR APPLICATION AS PHARMACEUTICALS
专利权人:
SANOFI-AVENTIS
发明人:
ShEFER Mattias (DE),ШЕФЕР Маттиас (DE),PERNERShTORFER Jozef (DE),ПЕРНЕРШТОРФЕР Йозеф (DE),KADERAJT Diter (DE),КАДЕРАЙТ Дитер (DE),ShTROBEL' Khartmut (DE),ШТРОБЕЛЬ Хартмут (DE),ChEKhTIZKIJ Verngard (DE,SHEFER MATTIAS,ШЕФЕР Маттиас,PERNERSHTORFER JOZEF,ПЕРНЕРШТОРФЕР Йозеф,KADERAJT DITER,КАДЕРАЙТ Дитер,SHTROBEL KHARTMUT,ШТРОБЕЛЬ Хартмут,CHEKHTIZKIJ VERNGARD,ЧЕХТИЗКИЙ Вернгард,CHEHN L. CHARLI,ЧЭНЬ Л. Ч
申请号:
RU2010149611/04
公开号:
RU0002529484C2
申请日:
2009.04.22
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compound of formula (I) , where ring A is cycloalkane ring with number of members from 3 to 7, benzene ring or monocyclic 5-member or 6-member aromatic heterocyclic ring, containing 1 heteromember of ring, selected from the group, containing N and S, and benzene and heterocyclic rings can optionally have one or two similar or different substituents, selected from the group, containing halogen, HO-, R1-O-, H2N-C(O)- and NC-; Y is selected from the group, containing S, C(R12)=C(R13) and C(R15)=N; Z is selected from the group, containing C(R16); R1, R30, R33, R35, R54 and R55 independently on each other group R1, R30, R33, R35, R54 and R55 are selected from the group, containing (C1-C6)-alkyl, (C2-C6)-alkenyl, (C3-C7)-cycloalkyl and (C3-C7)-cycloalkyl-(C1-C4)-alkyl-, and all of them can optionally have one or more similar or different substituents R70; R3 and R5 represent hydrogen; R4 and R6 are selected independently on each other, from the group, containing hydrogen and , (C1-C4)-alkyl; R12, R13, R15 and R16 are selected independently on each other, from the group, containing hydrogen, halogen and O2N-; R20 is selected from the group, containing hydrogen and (C1-C4)-alkyl; one of the groups R21 and R22 is group of formula II: R24-R23-, and the other of groups R21 and R22 is selected from the group, containing hydrogen, halogen, R30, HO-, R30-O-, R30-S(O)m-, H2N-, R30-NH-, R30-N(R30)-, R30-C(O)- and NC-; R23 is chain, containing from 1 to 5 chain members of which 0 or 1 chain member is heteromember of chain, selected from the group, containing N(R25), O, S, with other chain members being similar or different groups C(R26)(R26), where two adjacent groups can be bound to each other by double bond; R24 is selected from the group, containing hydrogen, R31, R31-O-, R31-NH-, R31-N(R31)-, R31-C(O)-NH-, HO-C(O)- and monocyclic, bicyclic or tricyclic ring with number of members from 5 to 10, which is saturated or n
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