A compound of formula 1 ** Formula ** in which R1 is phenyl or a five or six membered heteroaryl, in which one, two or three elements are replaced by an element independently selected from the group consisting of N, O or S； each ring being optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, O2N-, NC-, H2N-, HO-, R1.1, R1.1O-, R1.2, R1.3S -, R1.3 (O) S- and R1.3 (O) 2S-； R1.1 is independently selected from the group consisting of -C 1-6 alkyl-, C 3-6 cycloalkyl, C 1-6 haloalkyl and C 3-6 halocycloalkyl； R1.2 is HO-C1-6 alkyl- or R1.1-O-C1-6 alkyl； R1.3 is independently selected from the group consisting of H, HO-, R1.1 and R1.2； R2 is phenyl or a five or six membered heteroaryl, in which one or two elements are replaced by an element independently selected from the group consisting of N, O or S； each ring being optionally substituted with a substituent independently selected from the group consisting of halogen, -C 1-4 alkyl, -C 1-4 alkyl- and -C 1-4 alkyl-O-； R3 is a residue independently selected from the group consisting of * R3.1 -； * R3.2 (O) C-； * R3.2O (O) C-； * R3.2O (O) C-A-； * R3.2S-； R3.2 (O) S-； R3.2 (O) 2S-； * (R3.2) 2N (O) C and * (R3.2) 2N (O) C-A-； R3.1 is independently selected from the group consisting of H, R3.3, R3.4, -C 1-6 alkyl-C 3-6 cycloalkyl and C 3-6 cycloalkyl-C 1-6 alkyl, each optionally substituted with one or two substituents independently selected from R3.1.1-； R3.1.1 is selected from the group consisting of HO-, halogen, NC-, R3.3O-, R3.5, R3.6 and R3.7 or R3.1.1 represents a ring independently selected from phenyl and a heterocyclic ring of four members containing an element selected independently from N, O, S, S (O) and S (O) 2； R3.1.1 represents a five or six membered heterocyclic or heteroaryl ring containing one, two or three elements independently selected from N, O, S, S (O) and S (O) 2； each of the rings optionally substituted with one or two substituents inde
