MASTALERZ, HAROLD,WITTMAN, MARK D.,ZIMMERMANN, KURT,SAULNIER, MARK G.,VELAPARTHI, UPENDER,VYAS, DOLATRAI M.,ZHANG, GUIFEN,JOHNSON, WALTER LEWIS,FRENNESSON, DAVID B.,SANG, XIAOPENG,LIU, PEIYING,LANGLEY
申请号：
ES07799265
公开号：
ES2493566T3
申请日:
2007.07.03
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula I ** Formula ** in which: Q1 is aryl, substituted aryl or heteroaryl； X is C>； = O, C>； = S, C>； = NR9 or CH2； R1, R2, and R3 are independently hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, hydroxy, alkoxy, halogen, haloalkyl, haloalkoxy, alkanoyl, amino, aminoalkyl, alkylamino, amide, substituted amide, carbamate, ureido, cyano , sulfonamido, substituted sulfanamido, alkylsulfone, nitro, thio, thioalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, carboxy, alkoxycarbonyl, alkylcarbonyloxy, carbamoyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl or alkylcarbonyl； R4 is hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, halogen, haloalkyl, haloalkoxy, oxo, aryloxy, arylalkyl, arylalkyl, alkanoyl, alkanoyloxy, amino, aminoalkyl, alkylamino, hydroxyalkyl, amide, substituted amide, carbamate, substituted carbamate, ureido, cyano, sulfonamide, substituted sulfonamide, alkylsulfone, heterocycloalkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkylalkyl, cycloalkylalkoxy, nitro, thio, thioalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, carboxy, alkoxycarbonyl, alkylcarbonyloxy, carbamoyl, alkenyl, substituted alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, heteroaryloxy, arylheteroaryl, arylalkoxycarbonyl, heteroarylalkyl, heteroarylalkoxy, aryloxyalkyl, aryloxyaryl, heterocycle, substituted heterocycle, alkylcarbonyl, heteroalkenyl, heteroalkynyl, arylamino, arylalkylamino, alkanoylamino, aroylamino, arilalcanoilamino, ar ilium, arylalkylthio, arylsulfonyl, arylalkyl sulfonyl, alkylsulfonyl, arylcarbonylamino or alkylaminocarbonyl； R5 is hydrogen, halogen, cyano, alkyl or substituted alkyl； R6 is independently hydrogen, alkyl, substituted alkyl, alkylidene, substituted alkylidene, hydroxy, alkoxy, halogen, haloalkyl, haloalkoxy, oxo, aryloxy, arylalkyl, arylalkyloxy, alkanoyl, alkanoyloxy, amino, aminoalkyl, alkylamino, hydroxyalkyl, amide, substitut
