AM ENDE, Christopher William,FISH, Benjamin Adam,GREEN, Michael Eric,JOHNSON, Douglas Scott,MULLINS, Patrick Bradley,O'DONNELL, Christopher John,PETTERSSON, Martin Youngjin,STIFF, Cory Michael,SUBRAMA
申请号：
ES12713360
公开号：
ES2602794T3
申请日:
2012.03.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having the structure of Formula I: ** Formula ** in which: X is a 5- to 14-membered heteroaryl containing 1-3 heteroatoms； R1 is hydrogen, halogen, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl or C2-6 alkynyl； wherein said alkyl, cycloalkyl, alkenyl or alkynyl may be optionally and independently substituted with one to three fluoro, cyano, -CF3, hydroxyl or C1-6 alkoxy groups； R2a and R2b each time they appear are each independently hydrogen, fluoro, cyano, -CF3, C1-6 alkyl, C3-6 cycloalkyl, (C4-10) cycloalkyl, C2-6 alkenyl, C2-6 alkylidene or C2- alkynyl 6； wherein said alkyl, cycloalkyl, bicycloalkyl, alkenyl, alkylidene or alkynyl may be optionally and independently substituted with cyano, C1-3 alkyl or one to three fluoro； or R2a and R2b together with the carbon to which they are attached form a 3 to 5 membered cycloalkyl optionally substituted with one to three R8； R3 is - (C (R11) 2) t- (C6-10 aryl) or - (C (R11) 2) t- (5-14 membered heteroaryl)； wherein said aryl or heteroaryl moieties may be optionally substituted independently with one to five R10； R4a and R4b are each independently hydrogen, -CF3 or C1-6 alkyl, wherein said alkyl is optionally substituted with one to three -CF3, cyano or fluoro； or R4a and R4b together with the carbon to which they are attached form a 3 to 5 membered cycloalkyl, wherein said cycloalkyl is optionally substituted with one to three -CF3, cyano, fluoro or C1-6 alkyl； R5a and R5b each time they appear are each independently hydrogen, -CF3 or C1-6 alkyl, wherein said alkyl is optionally substituted with one to three -CF3, cyano or fluoro； or R5a and R5b together with the carbon to which they are attached form a 3 to 5 membered cycloalkyl, wherein said cycloalkyl is optionally substituted with one to three -CF3, cyano, fluoro or C1-6 alkyl； R6, R7 and R8 are independently hydrogen, -CF3, cyano, halogen, C1-6 alkyl or -OR9； provided that R6 and R7 cannot be both -OH； R9 is hydrogen, C1-6 alkyl, C3-6 cycloalkyl, C3-6 alkeny
