Frank OSTERKAMP,Christiane SMERLING,Ulrich REINEKE,Christian HAASE,Jan UNGEWIß
申请号:
US14650437
公开号:
US20150299133A1
申请日:
2013.12.06
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention is related to a compound of formula (I) wherein R1 is selected from the group consisting of hydrogen, methyl and cyclopropylmethyl AA-COOH is an amino acid selected from the group consisting of 2-amino-2-adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.1]nonane-9-carboxylic acid R2 is selected from the group consisting of (C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C5)cycloalkylmethyl, halogen, nitro and trifluoromethyl ALK is (C2-C5)alkylidene R3, R4 and R5 are each and independently selected from the group consisting of hydrogen and (C1-C4)alkyl under the proviso that one of R3, R4 and R5 is of the formula (II) wherein ALK′ is (C2-C5)alkylidene R6 is selected from the group consisting of hydrogen and (C1-C4)alkyl and R7 is selected from the group consisting of H and an Effector moiety or a pharmacologically acceptable salt, solvate or hydrate thereof.