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Spiro (piperidine-4, 2 ' -pyrrolidine) -1- (3, 5- trifluoromethyl phenyl) methylcarboxamides as NK1 tachikynin receptor antagonists
专利权人:
Glaxo Wellcome Manufacturing Pte Ltd
发明人:
Alvaro, Giuseppe,Marasco, Agostino,Castiglioni, Emiliano
申请号:
AU2009242120
公开号:
AU2009242120B2
申请日:
2009.04.29
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R is hydrogen or C alkyl; R is hydrogen, C alkyl, C(O)OH, C(O)NH or (C alkylene)R; R and R are independently hydrogen, C alkyl or R together with R and together with the carbon atom to which they are attached form a C cycloalkyl group; R is C alkyl, C alkoxy or halogen; R and R are independently hydrogen, hydroxy, halogen, C(O)NH, C(O)OH or (C alkylene) R; R and R are independently hydrogen or halogen; R is hydrogen, (C alkylene)R, C(O)NH, C(O)OH or R together with R form a 6 membered heterocyclic ring optionally containing a further heteroatom selected from oxygen, sulphur or nitrogen; R is hydrogen, halogen, hydroxy, C(O)NH, C(O)NH(C alkyl), C(O)N(C alkyl) or C(O)OH; n is O, 1 or 2. processes for their preparation, to compositions containing them and to their use in the treatment of diseases and conditions for which antagonism of NK1 is beneficial.
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