LUKIN, KIRILL A.,CHI-PING HSU, MARGARET,FERNANDO, DILINIE P.,KOTECKI, BRIAN J.,LEANNA, MARVIN R.
申请号：
ES07760624
公开号：
ES2385404T3
申请日:
2007.04.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A process for preparing a compound having the structural formula (I), ** Formula ** in which, R 1 is selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, cycloalkyl, cycloalkylalkyl, formyl, formylalkyl, haloalkoxy, haloalkyl, haloalkylthio, halogen, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, (CF3) 2 (HO) C -, RB (SO) 2RAN-, RAO (SO) 2-, RBO (SO) 2-, ZAZBN-, (ZAZBN) alkyl, (ZAZBN) carbonyl, (ZAZBN) carbonylalkyl and (ZAZBN) sulfonyl； R9, R10, R11 and R12 are each independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylcarbonyl, alkylcarbonylalkyl, alkylcarbonyloxy, alkylthio, alkynyl, aryl, carboxyl, carboxyl, carboxyl yl, cyano, cyanoalkyl, formyl, formylalkyl, haloalkoxyl, haloalkyl, haloalkylthio, halogen, heteroaryl, heterocycle, hydroxy, hydroxyalkyl, mercapto, mercaptoalkyl, nitro, (CF3) 2HO) C-, RB (SO) 2RAN-, RAO (SO ) 2-, RBO (SO) 2, ZAZBN-, (ZAZBN) alkyl, (ZAZBN) carbonyl, (ZAZBN) carbonyl alkyl and (ZAZBN) sulfonyl； RA is hydrogen or alkyl； RB is alkyl, aryl or arylalkyl； ZA is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, formyl, aryl and arylalkyl； and ZB is selected from the group consisting of alkyl, alkylcarbonyl, formyl, aryl and arylalkyl, comprising the steps of: (a) heating a mixture of a compound of formula (III), a base selected from the group consisting of sodium hydroxide, phosphate of potassium and cesium carbonate, and a composition consisting of a mixture of an compound of formula (IIa), a compound of formula (lIb) or a mixture thereof, in which P is selected from the group consisting of alkoxyalkyl, alkylcarbonyl , alkoxycarbonyl, arylalkyl, arylcarbonyl yaryloxycarbonyl； R1 is defined according to the compound
