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N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
专利权人:
SANOFI AVENTIS
发明人:
Evanno, Yannick,Dubois, Laurent,Malanda, Andre
申请号:
AU2007279166
公开号:
AU2007279166B2
申请日:
2007.07.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to compounds of general formula (I): in which Xis a hydrogen or halogen atom or a (C-C)-alkyl, (C-C)-cycloalkyl,(C-C)-cycloalkyl-(C-C)-alkylene,(C-C)-fluoroalkyl, cyano, C(O)NRR,nitro, (C-C)-thioalkyl, -S(O)-(C-C)-alkyl,-S(O)-(C-C)-alkyl, SONRRaryl-(C-C)-alkylene, aryl or heteroaryl group, thearyl and the heteroaryl being optionally substituted; X is a hydrogenor halogen atom or a (C-C)-alkyl, (C-C)-cycloalkyl,(C-C)-cycloalkyl-(C-C)-alkylene,(C-C)-fluoroalkyl, (C-C)-alkoxyl,(C-C)-cycloalkyl-(C-C)-alkylene-O-,(C-C)-fluoroalkoxyl, cyano, C(O)NRR,(C-C)-thioalkyl, -S(O)-(C-C)-alkyl,-S(O)-(C-C)-alkyl, SONRR,aryl-(C-C)-alkylene, aryl or heteroaryl group, thearyl and the heteroaryl being optionally substituted; X and Xare, independently of one another, a hydrogen or halogen atom or a (C-C)-alkyl,(C-C)-cycloalkyl, (C-C)-cycloalkyl-(C-C)-alkylene,(C-C)-fluoroalkyl, (C-C)-alkoxyl,(C-C)-cycloalkyl-(C-C)-alkylene-O-,(C-C)-fluoroalkoxyl, cyano, C(O)NRR,nitro, NRR, (C-C)-thioalkyl,-S(O)-(C-C)-alkyl, -S(O)-(C-C)-alkyl,SONRR, NRCOR, NRSOR,aryl-(C-C)-alkylene, aryl or heteroaryl group, thearyl and the heteroaryl being optionally substituted; Z, Z,Z and Z are, independently of one another, a nitrogen atomor a C(R) group; n is equal to 0, 1, 2 or 3; Y is an optionally substitutedaryl or heteroaryl; Ra and Rb are, independently of one another, a hydrogen atomor a (C-C)alkyl, (C-C)-cycloalkyl,(C-C)-cycloalkyl-(C-C)-alkylene,(C-C)-fluoroalkyl, hydroxyl, (C-C)-alkoxyl,(C-C)-cycloalkyl-(C-C)-alkylene-O-,(C-C)-fluoroalkoxyl, aryl or heteroaryl group, whereinRa and Rb may be optionally substituted; in the form of a base or an addition saltwith an acid, and also in the form of a hydrate or of a solvate. Process for the preparationthereof and therapeutic use.
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