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Derivados químicos de jasmonato, composiciones farmacéuticas y métodos de uso de los mismos
专利权人:
Ramot at Tel Aviv University; Ltd.
发明人:
Kashman, Yoel,Flescher, Eliezer,Herzberg, Max
申请号:
ES13159825
公开号:
ES2576980T3
申请日:
2006.12.07
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound represented by the structure of Formula I: Formula ** ** wherein in Formula I: A is COR1 R1 is a heteroaryloxy R2 is selected from the group consisting of hydrogen, C1-C12 substituted or unsubstituted, C3-C8 unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted, OR8, oxo and NR9aR9b R3, R4, R5, R6 and R7 are each independently selected from the group consisting of hydrogen, C1-C12 substituted or unsubstituted alkyl, C1-C12 substituted or unsubstituted, C3-C8 unsubstituted or substituted, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and OR8 NR9aR9b, oy R6 together with the carbons to which they are attached form a C3-C8 cycloalkyl or C3-C8 cycloalkyl substituted by halo or one of R5 and R6 represents an oxygen atom which is bonded to C6, thereby forming a heterocyclic ring of 6 or 5-membered oxygen containing, respectively wherein the bond between C9 and C10 can be a single or double bond R8, R9a and R9b each independently selected from the group consisting of hydrogen, C1-C12 substituted or unsubstituted, C3-C8 unsubstituted or substituted, unsubstituted or substituted aryl, substituted heteroaryl or substituted unsubstituted glycosyl alkyl, or R9a and R9b can together with the nitrogen to which they are attached form a heterocycle unsubstituted or substituted or a heteroaromatic ring optionally containing one or more heteroatoms selected from O, N and S additional O. n is selected from 1 and 2 including salts, hydrates, solvates, polymorphs, optical isomers, geometrical isomers, enantiomers, diastereomers, and mixtures thereof.Un compuesto representado por la estructura de Fórmula I:**Fórmula** En el que en la Fórmula I: A es COR1 R1 es un heteroariloxi R2 se selecciona del grupo que consiste en hidrógeno, alquilo C1-C12 sustituido o no sustituido, cicloalquilo C3-C8 no sustituido o sustituido, arilo no sustituido o sustituido, heteroarilo no sustituido o sustituido, OR8, o
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