CHEN, LI,DILLON, MICHAEL PATRICK,FENG, LICHUN,LAI, YINGJIE,YANG, MINMIN
申请号：
ES09768366
公开号：
ES2487524T3
申请日:
2009.12.07
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula I: ** Formula ** or pharmaceutically acceptable salts thereof, wherein: R1 is optionally substituted thiadiazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted pyrimidinyl or optionally substituted thiophenyl, R3 is hydrogen, C1-6 alkyl or cyano, R4 is hydrogen or C1-6 alkyl, R5 is C1-6 alkyl, C1-6 haloalkyl, C1-6 alkyloxy-C1-6 alkyl, hydroxyalkyl- C 1-6, N-C 1-6 alkylamino, N, N-C 1-4 alkylamino, C 3-7 cycloalkyl, aryl, heteroaryl, heterocyclyl, C 3-7 cycloalkyl-C 1-6 alkyl, heteroaryl-C 1-6 alkyl 6, heterocyclyl-C 1-6 alkyl, aryl-C 1-6 alkyl, aryloxy-C 1-6 alkyl, - (CRaRb) mC (O) -R8 ', in which: m is 0 or 1； Ra * and Rb, each independently, is hydrogen or C 1-6 alkyl, and R 8 'is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, aryl, heteroaryl, heterocyclyl, C 3-7 alkyl- C1-6, aryl-alkyl, heteroaryl-C1-6-alkyl, heterocyclyl-C1-6-alkyl, cycloalkyloxy-C3-7, aryloxy, heteroaryloxy, heterocyclyloxy, cycloalkyloxy-C3-7-C1-6-alkyl, aryloxy- C1-6alkyl； heteroaryloxy-C1-6 alkyl, heterocyclyloxy-C1-6 alkyl, or -NR9R10, in which: R9 is hydrogen or C1-6 alkyl, and R10 is hydrogen, C1-6 alkyl, C3-7 cycloalkyl , aryl, heteroaryl, heterocyclyl, cycloalkyl-C3-7-C1-6 alkyl, aryl-C1-6 alkyl, heteroarylalkyl or heterocyclyl-C1-6 alkyl, and R6, R7 and R8, each independently, is hydrogen , C1-6 alkyl, C1-6 alkyloxy, halo, C1-6 haloalkyl or cyano.Compuesto de fórmula I:**Fórmula** o sales farmacéuticamente aceptables de los mismos, en los que: R1 es tiadiazolilo sustituido opcionalmente, R2 es fenilo sustituido opcionalmente, piridinilo sustituido opcionalmente, pirimidinilo sustituido opcionalmente, piridazinilo sustituido opcionalmente o tiofenilo sustituido opcionalmente, R3 es hidrógeno, alquilo-C1-6 o ciano, R4 es hidrógeno o alquilo-C1-6, R5 es alquilo-C1-6, haloalquilo-C1-6, alquiloxi-C1-6-alquilo-C1-6, hidroxialquilo-C1-6, N-alquilamino-C1-6, N,N-dialquilamino-C1-4, cicloalquilo-
