Systems and methods for configuring a stereo-electroencephalography to target specific brain regions that are part of large scale neural networks responsible for neurological disorders are described. A hypothesis related to a large scale neural network responsible for a neurological disorder within patients brain can be received. Coordinates for implantation of at least two depth electrodes in the patients brain can be determined based on the hypothesis. Electrodes to be implanted can be selected for each of the coordinates. The electrodes can be designed and used to target these specific brain regions, including an insula electrode, a parietal-frontal electrode, a hippocampo electrode, and a perisylvian electrode. A visualization that includes the coordinates and the selected electrodes can be displayed, so that a surgeon can implant the selected electrodes into the patients brain according to the coordinates to test the hypothesis.
