Novel siRNA structure that suppresses off-target effect as much as possible and does not saturate RNAi mechanism and use thereof

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专利权人:

イ ドンギ

发明人:

イ ドンギ,チャン チャンイル

申请号：

JP2010539301

公开号：

JP5624474B2

申请日:

2008.12.18

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to a novel siRNA structure and the use thereof. More particularly, the invention relates to a double-stranded small interfering RNA molecule (siRNA molecule) comprising a 19-21 nucleotide (nt) antisense strand and a 15-19 nt sense strand having a sequence complementary to the antisense sequence, wherein the 5&prime； end of the antisense strand has a blunt end and the 3&prime； end of the antisense strand has an overhang, and to a method for silencing the expression of a target gene using the siRNA molecule.

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中国工程科技知识中心

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http://www.ckcest.cn/home/