A small interfering ribonucleic acids (siRNA) for interfering viral replication is disclosed, which is a single-stranded or double-stranded RNA with a gene-specific sequence, for interfering an expression of a target viral gene in an animal cell. Moreover, a recombinant plasmid is disclosed, which may include a complementary deoxyribonucleic acids (cDNA) sequence of the siRNA, and the recombinant plasmid is introduced into the animal cell to express the siRNA. Furthermore, a medical composition of interfering a target viral gene is disclosed, which may include the siRNA combined with a pharmaceutically available vehicle, for interfering the target viral gene, thereby applying on treatment of the virus-infected animal.本發明是揭露一種小型干擾性核醣核酸分子,其係具有專一性序列的單股或雙股核醣核酸,用以干擾動物細胞內之病毒的目標基因之表現量。其次,本發明亦揭露一種重組質體,此重組質體可包含與上述單股或雙股核醣核酸分子之專一性序列互補的去氧核醣核酸序列,用以導入至動物細胞內表現小型干擾性核醣核酸分子。再者,本發明更揭露一種干擾病毒目標基因表現量的醫藥組合物,此醫藥組合物可包含上述專一性序列的單股或雙股核醣核酸分子以及藥學上可接受的載劑,用以干擾動物細胞內之病毒的目標基因之表現量,從而治療受病毒感染之動物體。100...RNA 1101...序列110...第二序列120...第一序列121...雙股核苷酸結構121a...序列123...單股核苷酸環型結構
