BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS AND MAKING AND USE THEREOF

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专利权人:

发明人:

申请号：

EP15816302.2

公开号：

EP3226907A1

申请日:

2015.12.02

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

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中国工程科技知识中心

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http://www.ckcest.cn/home/