Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods and making and use thereof

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专利权人:

KEMPHARM INC.

发明人:

申请号：

IL25247217

公开号：

IL252472D0

申请日:

2017.05.23

申请国别(地区):

IL

年份:

2017

代理人:

摘要：

The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/