Travis Mickle,Sven Guenther,Sanjib Bera,Jaroslaw Kanski,Andrea Martin
申请号：
US16054578
公开号：
US20180338968A1
申请日:
2018.08.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
