Megan Alene Cloonan Foley,Kevin Wayne KUNTZ,Lorna Helen MITCHELL,Michael John MUNCHHOF,Darren Martin HARVEY
申请号：
US16423618
公开号：
US20200048195A1
申请日:
2019.05.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides pyrrolidine carboxamide compounds having Formula I and the pharmaceutically acceptable salts and solvates thereof, wherein A, B, X, Y, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
