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SUBSTITUTED PYRROLIDINE COMPOUNDS
专利权人:
EPIZYME; INC.
发明人:
Megan Alene Cloonan Foley,Kevin Wayne Kuntz,Lorna Helen Mitchell,Michael John Munchhof,Darren Martin Harvey
申请号:
US16531798
公开号:
US20200102314A1
申请日:
2019.08.05
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present disclosure provides substituted pyrrolidine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
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