Lorna Helen Mitchell,Andrew Simon Bell,Richard Chesworth,Megan Alene Cloonan Foley,Kevin Wayne Kuntz,James Edward John Mills,Michael John Munchhof
申请号：
US15510588
公开号：
US10577363B2
申请日:
2015.09.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure provides substituted piperidine compounds having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
