FOLEY, MEGAN ALENE CLOONAN,KUNTZ, KEVIN WAYNE,MITCHELL, LORNA HELEN,MUNCHHOF, MICHAEL JOHN,HARVEY, DARREN MARTIN
申请号：
CA2960277
公开号：
CA2960277A1
申请日:
2015.09.09
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure provides pyrrolidine carboxamide compounds having Formula I and the pharmaceutically acceptable salts and solvates thereof, wherein A, B, X, Y, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.
