KEVIN HON LUEN LAU,JASON BURCH,ZHONGHUA PEI,FREDERICK BROOKFIELD,DANIEL FRED ORTWINE,COLIN H. MACKINNON,RICHARD A. GOLDSMITH
申请号：
ARP130102838
公开号：
AR092088A1
申请日:
2013.08.09
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a compound of the formula (1) or stereoisomers or a pharmaceutically acceptable Salt thereof, in which: The cycloalkyl ring is a 5 - or 7 links heterociclilo 5 - 7 links； p is the number of 0, 1, 2, 3, 4, 5, 6, 7, or 8； each is independently a r u1d43 enl Ace, c u2081 u208b u2081 u2082 Hydrogen, alkyl, alquenilo c u2082 u208b u2081 u2082, alquinilo c u2082 u208b u2081 u2082, alquileno c u2081 u208b u2086, alquenileno c u2082 u208b u2086,Alquinileno c u2082 u208b u2086, halogen, - CN, - or u2077 sr u2077 nr u2077r u2078, -, -, - cf u2083 chf u2082 ch u2082f, -, -, - ocf u2083, no u2082 -, - C (o) r u2077, - C (o) or u2077, - C (o) - nr u2077r u2078, nr u2077c (or r u2078 - S (o), u2081 u208b u2082r u2077), nr u2077s u2081 u208b u2082r u2078 - (OR) - S (o) u2081 u208b u2082nr u2077r u2078 c u2083 u208b u2086, cycloalkyl, heterociclilo 3 - 10 Links or ar ILO 6 - 10 links, each r u1d43, that is not a link or Hydrogen, optionally substituted by r u2079 is Independence,Or two r u1d43 along with Atoms that are United to form a alquileno c u2081 u208b u2086, alquenileno c u2082 u208b u2086, alquinileno c u2082 u208b u2086 c u2083 u208b u2086 heterociclilo, cycloalkyl, aryl 3 - 10 6 - 10 Links or links, such heterociclilo cycloalkyl, optionally substituted aryl and are S with r u2079 Independence,Or two r u1d43 together with the Atom to form a United c u2083 u208b u2086 cycloalkyl or heterociclilo 3 - 10 links, such heterociclilo are optionally substituted cycloalkyl and independently by r u2079； r u2075 is alquileno c u2081 u208b u2086, alquenileno c u2082 u208b u2086, alquinileno c u2082 u208b u2086 or Heterociclilo 3 - 10 links, such alquileno,Alquenileno with independence and alquinileno are optionally substituted by Halogen, alkyl c u2081 u208b u2081 u2082, Oxo, alquenilo c u2082 u208b u2081 u2082, alquinilo c u2082 u208b u2081 u2082 or u00b9 u2076 sr u00b9 u2076, -, -, - nr u00b9 u2076r u00b9 u2077, - CN, - cf u2083 chf u2082 ch u2082f, -, -, - ocf u2083 c
