КУДУК Скотт Д. (US),ЧАНГ Рональд К. (US),ГРИШОК Томас Дж. (US)
申请号：
RU2012112064/04
公开号：
RU2012112064A
申请日:
2010.08.26
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. The compound of formula (I) or a pharmaceutically acceptable salt thereof, in which X-Y is selected from the group consisting of (1) -O-CRR -, (2) -CRR-O -, (3) -CRR-SR -, ( 4) -CRR-NR- and (5) -NR-CRR-, where each R and R are independently selected from the group consisting of (a) hydrogen and (b) -Calkyl, and R is selected from the group including (a) hydrogen, (b) -C (= O) -Calkyl, (c) -Calkyl, (d) -C (= O) -CH-CH, (e) -S (= O) -Calkyl, R are selected from the group consisting of (1) hydrogen and (2) hydroxy, provided that when XY is —O — CRR—, CRR — O— or CRR-SR—, then R is hydroxy in the isomeric position: R is selected from the group consisting of (1) -Saryl or (2 ) -heteroaryl representing the aromatic cyclic group containing from five to twelve atoms of the cycle, while the atoms of the cycle are selected from C, O, N, N → O or S, at least one of which is O, N, N → O or S, wherein the aryl or heteroaryl group R is optionally substituted with one or more (a) halogen, (b) hydroxy, (c) -NRR, (d) -Calkyl, (e) -O-Ci-alkyl, (f) -Salkenyl, (g) - С (= О) - (О) -R, (h) -С (= О) -NR, (i) -S (= О) -R, (j) -SR, (k) -CN, (l ) -Saryl, (m) heteroaryl, which is an aromatic cyclic group containing from five to twelve ring atoms, while the ring atoms are selected from C, O, N, N → O whether S, at least one of which is O, N, N → O or S, (n) Si (R), (o) = S, where the alkyl, alkenyl, aryl or heteroaryl group is optionally substituted with one or more (a) halogen, (b) hydroxyl, (c) -alkyl, (d) -SR, (e) -NRR, (f) -O-C1-6alkyl, where the alkyl group is optionally substituted with one or more halogen atoms； R and R, or R and R are independently selected from the group consisting of (1) hydrogen or (2) -Cialkyl, where the alkyl is optionally substituted with one or more (a) halogen, (b) hydroxyl, (c) -O-Ci-alkyl, (d) -NRR, (e) -C (= O) - (O) -Calkyl, or R and R, or R and R are connected together with at1. Соединение формулы (I)или его фармацевтически приемлемая соль, в которойX-Y
