The compound is new. The compound of formula (I), their pharmaceutical useful derivatives, solvate, salts, tautomers and stereoisomers, are new. For formula (I), R 1> : Ar, benzo-2,1,3-thiadiazolyl or Het, where Ar is selected from phenyl, naphthyl or biphenyl, which are unsubstituted or once, twice or thrice substituted by hal, A, N(R 3>) 2, [C(R 3>) 2] nOR 3>, [C(R 3>) 2] nN(R 3>) 2, SR 3>, NO 2>, CN, COOR 3>, CON(R 3>) 2, NR 3>COA, NR 3>SO 2A, SO 2N(R 3>) 2, S(O) mA, CO-Het, Het, O[C(R 3>) 2] nN(R 3>) 2, O[C(R 3>) 2] nHet, NHCOOA, NHCON(R 3>) 2, NHCOO[C(R 3>) 2] nN(R 3>) 2, NHCOO[C(R 3>) 2] nHet, NHCONH[C(R 3>) 2] nN(R3)2, NHCONH[C(R 3>) 2] nHet, OCONH[C(R 3>) 2] nN(R3)2, OCONH[C(R 3>) 2] nHet, CONR 3>[C(R 3>) 2] nN(R 3>) 2, CONR 3>[C(R 3>) 2] nHet or COA, and Het is once, twice or thrice saturated or unsaturated or aromatic heterocycles with 1-4 N-, O- or S-atoms or piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridyl, pyrimidinyl, triazolyl, tetrazolyl, oxadiazolyl, thiadiazolyl, pyridazinyl, pyrazinyl, benzimidazolyl, benzotriazolyl, indolyl, benzo[1,3]dioxolyl, indazolyl, azabicyclo[3.2.1]octyl, azabicyclo[2.2.2]octyl, imidazolidinyl, azepanyl or benzo [2,1,3]thiadiazolyl, which are unsubstituted or once, twice or thrice substituted by halide, A, [C(R 3>) 2] nOR 3>, [C(R 3>) 2] nN(R 3>) 2, SR 3>, NO 2>, CN, COOR 3>, CON(R 3>) 2, NR 3>COA, NR 3>SO 2A, SO 2N(R 3>) 2, S(O) mA, CO-Het 1>, [C(R 3>) 2] nHet 1>, O[C(R 3>) 2] nN(R 3>) 2, O[C(R 3>) 2] nHet 1>, NHCOOA, NHCON(R 3>) 2, NHCOO[C(R 3>)2] nN(R 3>) 2, NHCOO[C(R 3>) 2] nHet 1>, NHCONH[C(R 3>) 2] nN(R 3>) 2, NHCONH[C(R 3>) 2] nHet 1>, OCONH[C(R 3>) 2] nN(R 3>) 2, OCONH[C(R 3>) 2] nHet 1>, [C(R 3>) 2] nOR 3>, [C(R 3>) 2] nNR 3>, CHO, COA, =S, =NH, =NA or =O (carboxylic oxygen) and where a nitrogen ring is oxidized, Het 1>is a saturated heterocycle with 1-2 N or O-atoms or pyrrolidinyl, piperidinyl, piperazinyl
