Monoclonal antibodies against antithrombin beta complexed with heparin

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专利权人:

Bayer Healthcare LLC

发明人:

Jin, Ye,Murphy, John, E.,Hermiston, Terry,Myles, Timothy,Dittmer, Frank,Strerath, Michael,Gritzan, Uwe

申请号：

AU2014236198

公开号：

AU2014236198A1

申请日:

2014.03.14

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ΑΤβΗ). These ΑΤβΗ binding proteins can block the anti-coagulant activity of ΑΤβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

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