Ye Jin,John E. Murphy,Terry Hermiston,Timothy Myles,Frank Dittmer,Michael Strerath,Uwe Gritzan
申请号：
US14770222
公开号：
US09908942B2
申请日:
2014.03.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.
