ZHAO, XIAO-YAN,WANG, ZHUOZHI,GU, JIAN-MING,KIM, JI-YUN,BAUZON, MAXINE,MURPHY, JOHN E.,MCLEAN, KIRK,JIN, FANG,MARQUARDT, TOBIAS,WANG, XINQUAN,WILMEN, ANDREAS
申请号：
CA2892750
公开号：
CA2892750A1
申请日:
2013.11.27
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Provided herein are antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human activated Protein C (aPC) with minimal binding to its zymogen Protein C (PC). Moreover, these aPC binding proteins could potentially block the anti-coagulant activity of aPC to induce coagulation. Therapeutic uses of these binders are described herein as are methods of panning and screening specific antibodies.
