Ye JIN,John E. MURPHY,Terry HERMISTON,Timothy MYLES,Frank DITTMER,Michael STRERATH,Uwe GRITZAN
申请号：
US15908705
公开号：
US20180244799A1
申请日:
2018.02.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.
